John B Porter Selected Research

Deferoxamine (Desferal)

1/2016	Efficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with nontransfusion-dependent thalassemia syndromes.
9/2015	Prevalence and distribution of iron overload in patients with transfusion-dependent anemias differs across geographic regions: results from the CORDELIA study.
6/2015	Effects of deferasirox-deferoxamine on myocardial and liver iron in patients with severe transfusional iron overload.
2/2015	Sustained improvements in myocardial T2* over 2 years in severely iron-overloaded patients with beta thalassemia major treated with deferasirox or deferoxamine.
3/2014	A 1-year randomized controlled trial of deferasirox vs deferoxamine for myocardial iron removal in β-thalassemia major (CORDELIA).
7/2013	Cardiovascular function and treatment in β-thalassemia major: a consensus statement from the American Heart Association.
5/2013	Treatment of heart failure in adults with thalassemia major: response in patients randomised to deferoxamine with or without deferiprone.
6/2012	Timed non-transferrin bound iron determinations probe the origin of chelatable iron pools during deferiprone regimens and predict chelation response.
10/2011	Iron chelation therapy in thalassemia major: a systematic review with meta-analyses of 1520 patients included on randomized clinical trials.
4/2010	Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overload.

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John B Porter Research Topics

Disease

49	Iron Overload 01/2022 - 06/2002
28	Thalassemia 01/2022 - 12/2007
23	beta-Thalassemia (Cooley's Anemia) 01/2020 - 07/2004
10	Anemia 03/2020 - 09/2007
9	Siderosis 03/2017 - 03/2010
9	Sickle Cell Anemia (Hemoglobin S Disease) 01/2016 - 09/2007
8	Cardiomyopathies (Cardiomyopathy) 03/2017 - 11/2004
8	Heart Failure 03/2017 - 06/2002
5	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 11/2018 - 12/2007
5	Fibrosis (Cirrhosis) 03/2017 - 06/2003
4	Stroke (Strokes) 03/2017 - 03/2011
4	Nausea 03/2016 - 10/2010
3	Inflammation (Inflammations) 03/2020 - 01/2009
3	Hemolysis 06/2015 - 01/2009
2	Hepatocellular Carcinoma (Hepatoma) 05/2020 - 01/2009
2	Exanthema (Rash) 01/2017 - 01/2011
2	Polycythemia (Erythrocytosis) 01/2016 - 01/2012
2	Pulmonary Hypertension 09/2013 - 04/2010
2	Hemochromatosis (Bronze Diabetes) 07/2013 - 03/2013
2	Aplastic Anemia (Anemia, Hypoplastic) 07/2013 - 10/2010
1	Neuroblastoma 05/2020
1	Inborn Genetic Diseases (Disease, Hereditary) 03/2020
1	Liver Diseases (Liver Disease) 03/2020
1	Necrosis 01/2020
1	Insulinoma 05/2019
1	Hemosiderosis 10/2017
1	Disease Progression 01/2017
1	Tics (Tic) 08/2016
1	Carcinogenesis 03/2016
1	Pneumonia (Pneumonitis) 03/2016
1	Hypoxia (Hypoxemia) 12/2014
1	Infections 08/2014
1	Osteonecrosis (Kienbock's Disease) 07/2014
1	Dyspnea (Shortness of Breath) 09/2013
1	Cardiotoxicity 07/2013
1	Sideroblastic Anemia 07/2013

Drug/Important Bio-Agent (IBA)

65	IronIBA 01/2022 - 06/2002
28	Deferasirox FDA Link 01/2019 - 10/2006
13	Deferoxamine (Desferal)FDA LinkGeneric 01/2016 - 11/2004
12	Ferritins (Ferritin)IBA 11/2020 - 12/2009
12	Chelating AgentsIBA 05/2019 - 10/2006
9	Transferrin (beta 2 Transferrin)IBA 03/2020 - 06/2005
6	Pharmaceutical PreparationsIBA 03/2016 - 10/2006
6	DeferiproneIBA 01/2016 - 06/2003
4	HepcidinsIBA 01/2017 - 01/2009
3	TabletsIBA 01/2019 - 05/2017
3	Growth Differentiation Factor 15IBA 01/2017 - 01/2009
3	Biomarkers (Surrogate Marker)IBA 01/2017 - 10/2011
2	Free RadicalsIBA 05/2020 - 05/2019
2	TeaIBA 01/2020 - 05/2019
2	Hemoglobins (Hemoglobin)IBA 01/2018 - 01/2016
2	hemoglobin LutonIBA 01/2016 - 01/2012
2	Oxygen (Dioxygen)IBA 01/2016 - 01/2012
2	Isoflurophate (DFP)FDA Link 05/2013 - 10/2011
2	4,5- dihydro- 2- (2- hydroxy- 3- (3,6,9- trioxadecyloxy)phenyl)- 4- methyl- 4- thiazolecarboxylic acidIBA 04/2012 - 04/2011
2	CreatinineIBA 07/2011 - 01/2011
2	Alanine Transaminase (SGPT)IBA 01/2011 - 09/2008
1	GlobinsIBA 01/2022
1	betibeglogene autotemcelIBA 01/2022
1	Fatty Acids (Saturated Fatty Acids)IBA 05/2020
1	LipidsIBA 05/2020
1	Ceruloplasmin (Ferroxidase)IBA 03/2020
1	Familial apoceruloplasmin deficiencyIBA 03/2020
1	NitrogenIBA 01/2020
1	CurcuminIBA 01/2020
1	Urea (Carbamide)FDA LinkGeneric 01/2020
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2020
1	Interleukin-6 (Interleukin 6)IBA 01/2020
1	Insulin (Novolin)FDA Link 05/2019
1	ferric ammonium citrate FDA Link 05/2019
1	Bovine Serum AlbuminIBA 05/2019
1	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 05/2019
1	apotransferrinIBA 10/2017
1	C.I. direct red 80IBA 03/2017
1	CollagenIBA 03/2017
1	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2016
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 01/2016
1	CobaltIBA 01/2016
1	ChromiumIBA 01/2016
1	Arginine (L-Arginine)FDA Link 06/2015
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 06/2015
1	Biological ProductsIBA 06/2015
1	Hemoglobin EIBA 01/2015
1	DiamondIBA 12/2014
1	metal transporting protein 1 (ferroportin)IBA 12/2014
1	Erythropoietin FDA Link 12/2014
1	Transferrin Receptors (Transferrin Receptor)IBA 12/2014
1	1- (N- acetyl- 6- aminohexyl)- 3- hydroxy- 2- methylpyridin- 4- oneIBA 09/2014
1	Alendronate (Alendronate Sodium)FDA LinkGeneric 07/2014
1	Sildenafil Citrate (Viagra)FDA Link 09/2013

Therapy/Procedure

24	Chelation Therapy (Therapy, Chelation) 01/2020 - 07/2004
9	Therapeutics 01/2017 - 09/2008
5	Blood Transfusion (Blood Transfusions) 01/2018 - 11/2011
3	Splenectomy 01/2017 - 10/2011
2	Heart Transplantation (Grafting, Heart) 03/2017 - 08/2014
2	Transplantation 03/2017 - 04/2011
2	Hematopoietic Stem Cell Transplantation 01/2017 - 03/2016
1	Stem Cell Transplantation 01/2017
1	Erythrocyte Transfusion 03/2016
1	Hip Prosthesis 01/2016